to check plug wire
remove wire from plug
remove plug from cylinder head
insert plug into plug lead connector
have assistant hold plug against head
crank engine
At this time, if the assistant screams in pain, you'll know that voltage is passing through the wire, through arm, and grounding to the engine or car where your assistant is leaning against it.
Alternatively, if assistant is astute enough not to receive the jolt, the plug will spark.
Either way, you will have proved the spark plug lead is okay.
NEXT TEST. One (or more) wires may be crossfiring, that is, the spark in one wire jumping through poor insulation to another wire. To check, separate all the wires, park in the dark, observe wires while running. You may see a spark where none should be, or you can hear it "tic-tic-tic" shorting each time that wire carries a spark. Replace offending wire and all should be better.